The Effect of Statins in Treatment of Raynaud"s Phenomenon in Scleroderma: A Case Series

Article type : Case Series | تاریخ ثبت : 2016/06/22

  • Authors

    1. Sahebari Maryam
    2. Javanbakht Aida
    3. Mirfeizi Zahra
  • abstract

    Introduction: Systemic sclerosis (SSc) is a systemic autoimmune disease of unknown etiology. It affects different organs such as small blood vessels and it has high mortality rate among rheumatic diseases. One of the recurrent reversible manifestations of vascular involvement which is caused by excessive vasospasm of digital arteries in SSc is Raynaud"s phenomenon (RP). More than 95% of SSc patients suffer from this complication and approximately 30% of these patients will have digital ulcer (DU) yearly. Cold weather and emotional stress are considered as the triggers of RP. DU augments dysfunction in fingertips by impairment of hand function and ischemic complications. Case Report: In this case series, we want to report 6 patients with RP and DU who fulfilled the criteria of SSc16 in Mashhad, Iran. 40 mg/night of atorvostatin for 3 months was added to their standard treatment regimen. Peripheral blood samples were collected for evaluating lipid profile at the beginning and end of the study. Body mass index (BMI) was calculated by body weight/height2 formula. Conclusion: Statins such as atorvastatin are useful for reducing RP and DU in SSc patients. This study proved that a dose of 40 mg atorvastatin can improve the quality of the patients" life, RP and ulcer formation.
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