Association between Downs syndrome and systemic lupus erythematosus

Article type : Case Series | تاریخ ثبت : 2020/03/25

  • Authors

    1. Rezaieyazdi Zahra
    2. Khodashahi Mandana
  • abstract

    People with Down’s syndrome (DS) show markedly rates of autoimmune disorders, whereby the immune system mistakenly attacks healthy tissues, while being protected from other conditions, such as most solid malignancies. Studies showed an increased prevalence of autoimmune disorders in Ds Patients but Ds Patients with systemic lupus erythematosus (SLE) rarely reported. Here we describe a 17-year-old male patient with DS who developed SLE. The patient fulfilled 6 of the revised criteria for the classification of SLE: malar rash, arthritis, pericarditis, positive ANA and positive anti-dsDNA. We reviewed five previous case reports and discussed whether the immune disorders in Down’s syndrome patients may predispose them to SLE as an autoimmune disease. The association between Down syndrome and systemic lupus erythematosus a is an alert for clinicians. The enhanced autoantibody production and apoptosis have major roles in the pathogenesis of SLE, it can be safely concluded that DS patients have some immune disorders that susceptible them to develop SLE more than the healthy population.
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